Resource Type

Journal Article 218

Conference Videos 5

Year

2024 1

2023 18

2022 32

2021 21

2020 21

2019 23

2018 16

2017 5

2016 8

2015 11

2014 8

2013 8

2012 6

2011 2

2010 6

2009 6

2008 11

2007 10

2006 1

2005 1

open ︾

Keywords

resistance 12

Antibiotic resistance genes 10

drug resistance 8

Antibiotic resistance 6

insulin resistance 6

Escherichia coli 3

Antibiotic resistance genes (ARGs) 3

Antibiotic resistance gene 2

Antibiotics 2

Antimicrobial resistance 2

Chlorination 2

Metagenomics 2

Resistome 2

Sulfonamide resistance genes 2

Wheat 2

antibiotic resistance 2

breeding 2

cancer 2

different 2

open ︾

Search scope:

排序： Display mode:

Mechanism of insulin resistance in obesity: a role of ATP

Frontiers of Medicine 2021, Volume 15, Issue 3,   Pages 372-382 doi: 10.1007/s11684-021-0862-5

Abstract: Obesity increases the risk of type 2 diabetes through the induction of insulin resistance.The mechanism of insulin resistance has been extensively investigated for more than 60 years, but theThe ATP overproduction contributes to the systemic insulin resistance through several mechanisms, suchInsulin resistance represents a feedback regulation of energy oversupply in cells to control mitochondrialInsulin resistance cuts down the substrate uptake to attenuate mitochondrial overloading.

Keywords： type 2 diabetes     energy expenditure     mitochondria     hyperinsulinemia     hyperglucagonemia     AMPK    

HTML PDF Collect

Insulin resistance and the metabolism of branched-chain amino acids

Jingyi Lu, Guoxiang Xie, Weiping Jia, Wei Jia

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 53-59 doi: 10.1007/s11684-013-0255-5

Abstract:

Insulin resistance (IR) is a key pathological feature of metabolic syndrome and subsequently causesThe BCAAs are particularly responsive to the inhibitory insulin action on amino acid release by skeletalmuscle and their metabolism is profoundly altered in insulin resistant conditions and/or insulin deficiencyAlthough increased circulating BCAA concentration in insulin resistant conditions has been noted for

Keywords： branched-chain amino acids     leucine     isoleucine     valine     insulin resistance    

HTML PDF Collect

Mechanisms of insulin resistance in obesity

Jianping Ye

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 14-24 doi: 10.1007/s11684-013-0262-6

Abstract:

Obesity increases the risk for type 2 diabetes through induction of insulin resistance.Treatment of type 2 diabetes has been limited by little translational knowledge of insulin resistancealthough there have been several well-documented hypotheses for insulin resistance.resistance, in which insulin resistance is a result of energy surplus in cells., which may apply to insulin resistance in aging and lipodystrophy.

Keywords： type 2 diabetes     energy expenditure     inflammation     lipotoxicity     mitochondria     hyperinsulinemia     adenosine monophosphate-activated protein kinase (AMPK)    

HTML PDF Collect

Lingguizhugan Decoction, a Chinese herbal formula, improves insulin resistance in overweight/obese subjects

Frontiers of Medicine 2022, Volume 16, Issue 5,   Pages 745-759 doi: 10.1007/s11684-021-0880-3

Abstract: Lingguizhugan Decoction (LGZG) has been investigated in basic studies, with satisfactory effects on insulinresistance in non-alcoholic fatty liver disease (NAFLD).The primary efficacy variable was homeostasis model assessment of insulin resistance (HOMA-IR).Low-dose LGZG effectively improved insulin resistance in overweight/obese subjects with NAFLD.

Keywords： insulin resistance     non-alcoholic fatty liver disease     Chinese herbal medicine     randomized controlled    

HTML PDF Collect

Role of exercise training on insulin resistance and TNF-α in high-fat diet rats

Hui SUN MD, Xiuling DENG MM, Fangxi XIAO MD, Lulu CHEN MD, Huiqing LI MD,

Frontiers of Medicine 2009, Volume 3, Issue 4,   Pages 403-407 doi: 10.1007/s11684-009-0071-0

Abstract: This study investigated the effect of exercise training on insulin resistance and serum and adipose TNF-α in high-fat diet-induced insulin-resistant rats.resistance model.group were significantly elevated, while the ISI decreased obviously, which suggested that insulin resistanceIn conclusion, exercise training ameliorates insulin resistance.

Keywords： exercise training     insulin resistance     tumor necrosis factor-α    

HTML PDF Collect

Inhibition of protein kinase B by Palmitate in the insulin signaling of HepG2 cells and the preventiveeffect of Arachidonic acid on insulin resistance

XIA Yanzhi, WAN Xuedong, DUAN Qiuhong, HE Shansu, WANG Ximing

Frontiers of Medicine 2007, Volume 1, Issue 2,   Pages 200-206 doi: 10.1007/s11684-007-0038-y

Abstract: Elevated plasma levels of free fatty acids (FFAs) may contribute to insulin resistance (IR) that is characteristic

Keywords： palmitate     characteristic     study     plasma     resistance    

HTML PDF Collect

Molecular mechanisms of fatty liver in obesity

Lixia Gan,Wei Xiang,Bin Xie,Liqing Yu

Frontiers of Medicine 2015, Volume 9, Issue 3,   Pages 275-287 doi: 10.1007/s11684-015-0410-2

Abstract: Insulin resistance associated with central obesity is the major cause of hepatic steatosis, which is

Keywords： nonalcoholic fatty liver disease     insulin resistance     obesity    

HTML PDF Collect

Zinc homeostasis in the metabolic syndrome and diabetes

Xiao Miao, Weixia Sun, Yaowen Fu, Lining Miao, Lu Cai

Frontiers of Medicine 2013, Volume 7, Issue 1,   Pages 31-52 doi: 10.1007/s11684-013-0251-9

Abstract: roles of Zn: (1) a constructive component of many important enzymes or proteins, (2) a requirement for insulinstorage and secretion, (3) a direct or indirect antioxidant action, and (4) an insulin-like action.

Keywords： zinc     zinc transporters     metallothionein     diabetes     diabetic complications     insulin resistance     antioxidant    

HTML PDF Collect

Xiao Ke Qing improves glycometabolism and ameliorates insulin resistance by regulating the PI3K/Akt pathway

Xiaoqing Li, Xinxin Li, Genbei Wang, Yan Xu, Yuanyuan Wang, Ruijia Hao, Xiaohui Ma

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 688-696 doi: 10.1007/s11684-018-0662-8

Abstract: Moreover, XKQ can ameliorate insulin resistance and upregulate the expression of IRS-1, PI3K (p85), p-AktXKQ is an effective drug for T2DM by ameliorating insulin resistance and regulating the PI3K/Akt signaling

Keywords： XKQ     type 2 diabetes mellitus     KKAy mice     PI3K/Akt pathway     diabetic liver disease    

HTML PDF Collect

Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes

Jianping Ye

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 139-145 doi: 10.1007/s11684-015-0377-z

Abstract:

In obesity, chronic inflammation is believed to induce insulin resistance and impairs adipose tissueof literature, it has been challenged by growing evidence that pro-inflammatory cytokines may favor insulinIL-15 suppresses lipogenesis, stimulates brown fat function, improves insulin sensitivity through weight

Keywords： inflammation     obesity     cytokine     energy expenditure     insulin resistance    

HTML PDF Collect

Metformin and metabolic diseases: a focus on hepatic aspects

Juan Zheng,Shih-Lung Woo,Xiang Hu,Rachel Botchlett,Lulu Chen,Yuqing Huo,Chaodong Wu

Frontiers of Medicine 2015, Volume 9, Issue 2,   Pages 173-186 doi: 10.1007/s11684-015-0384-0

Abstract: While generating beneficial effects on hyperglycemia, metformin also improves insulin resistance and

Keywords： metformin     diabetes     hepatic steatosis     inflammatory response     insulin resistance    

HTML PDF Collect

Mechanistic and therapeutic advances in non-alcoholic fatty liver disease by targeting the gut microbiota

Ruiting Han, Junli Ma, Houkai Li

Frontiers of Medicine 2018, Volume 12, Issue 6,   Pages 645-657 doi: 10.1007/s11684-018-0645-9

Abstract: underlying gut microbiota-mediated development of NAFLD include modulation of host energy metabolism, insulin

Keywords： gut microbiota     NAFLD     obesity     insulin resistance     bile acids     probiotic    

HTML PDF Collect

Effects of resistin on skeletal glucose metabolism

Fang-Ping LI, Zhi-Zhen LI, Miao ZHANG, Li YAN, Zu-Zhi FU

Frontiers of Medicine 2010, Volume 4, Issue 3,   Pages 329-335 doi: 10.1007/s11684-010-0091-9

Abstract: Resistin is an adipokine highly related to insulin resistance (IR).We observed that resistin was expressed in transfected myocytes, and resistin decreased insulin inducedIt is concluded that resistin inhibits insulin induced glucose uptake in myocytes by downregulating the

Keywords： resistin     insulin resistance     skeletal muscle    

HTML PDF Collect

Overcoming oral insulin delivery barriers: application of cell penetrating peptide and silica-based nanoporous

Huining HE, Junxiao YE, Jianyong SHENG, Jianxin WANG, Yongzhuo HUANG, Guanyi CHEN, Jingkang WANG, Victor C YANG

Frontiers of Chemical Science and Engineering 2013, Volume 7, Issue 1,   Pages 9-19 doi: 10.1007/s11705-013-1306-9

Abstract: Oral insulin delivery has received the most attention in insulin formulations due to its high patientHowever, oral insulin delivery has two major limitations: the enzymatic barrier that leads to rapid insulindegradation, and the mucosal barrier that limits insulin’s bioavailability.In vitro studies demonstrated that the CPP-insulin conjugates could facilitate cellular uptake of insulinwhile keeping insulin’s biologic functions intact.

Keywords： insulin     cell penetrating peptide     mucoadhesive composites     oral delivery    

HTML PDF Collect

Effects of resistin on insulin signaling in endothelial cells

Zhizhen LI, Fangping LI, Jianhong YE, Li YAN, Zuzhi FU

Frontiers of Medicine 2009, Volume 3, Issue 2,   Pages 136-140 doi: 10.1007/s11684-009-0029-2

Abstract: The objective of this study was to investigate the effects of resistin on insulin signaling in humanendothelial nitric oxide synthase (eNOS) phosphorylation levels of endothelial cells under basal or insulincould significantly inhibit Akt and eNOS phosphorylation and NO production in endothelial cells under insulinThese findings suggested that resistin exerted an inhibitory effect on NO production by inhibiting insulin

Keywords： resistin     endothelium     nitric oxide     endothelial nitric oxide synthase     Akt-binding protein     mouse    

HTML PDF Collect

Title Author Date Type Operation

Mechanism of insulin resistance in obesity: a role of ATP

Journal Article

Insulin resistance and the metabolism of branched-chain amino acids

Jingyi Lu, Guoxiang Xie, Weiping Jia, Wei Jia

Journal Article

Mechanisms of insulin resistance in obesity

Jianping Ye

Journal Article

Lingguizhugan Decoction, a Chinese herbal formula, improves insulin resistance in overweight/obese subjects

Journal Article

Role of exercise training on insulin resistance and TNF-α in high-fat diet rats

Hui SUN MD, Xiuling DENG MM, Fangxi XIAO MD, Lulu CHEN MD, Huiqing LI MD,

Journal Article

Inhibition of protein kinase B by Palmitate in the insulin signaling of HepG2 cells and the preventiveeffect of Arachidonic acid on insulin resistance

XIA Yanzhi, WAN Xuedong, DUAN Qiuhong, HE Shansu, WANG Ximing

Journal Article

Molecular mechanisms of fatty liver in obesity

Lixia Gan,Wei Xiang,Bin Xie,Liqing Yu

Journal Article

Zinc homeostasis in the metabolic syndrome and diabetes

Xiao Miao, Weixia Sun, Yaowen Fu, Lining Miao, Lu Cai

Journal Article

Xiao Ke Qing improves glycometabolism and ameliorates insulin resistance by regulating the PI3K/Akt pathway

Xiaoqing Li, Xinxin Li, Genbei Wang, Yan Xu, Yuanyuan Wang, Ruijia Hao, Xiaohui Ma

Journal Article

Beneficial metabolic activities of inflammatory cytokine interleukin 15 in obesity and type 2 diabetes

Jianping Ye

Journal Article

Metformin and metabolic diseases: a focus on hepatic aspects

Juan Zheng,Shih-Lung Woo,Xiang Hu,Rachel Botchlett,Lulu Chen,Yuqing Huo,Chaodong Wu

Journal Article

Mechanistic and therapeutic advances in non-alcoholic fatty liver disease by targeting the gut microbiota

Ruiting Han, Junli Ma, Houkai Li

Journal Article

Effects of resistin on skeletal glucose metabolism

Fang-Ping LI, Zhi-Zhen LI, Miao ZHANG, Li YAN, Zu-Zhi FU

Journal Article

Overcoming oral insulin delivery barriers: application of cell penetrating peptide and silica-based nanoporous

Huining HE, Junxiao YE, Jianyong SHENG, Jianxin WANG, Yongzhuo HUANG, Guanyi CHEN, Jingkang WANG, Victor C YANG

Journal Article

Effects of resistin on insulin signaling in endothelial cells

Zhizhen LI, Fangping LI, Jianhong YE, Li YAN, Zuzhi FU

Journal Article